Acne Patients at Significantly Higher Risk of Major Depression

acne

People with acne have a significantly increased risk of developing major depression, but only in the first five years after diagnosis, according to a study recently published in the British Journal of Dermatology.

Canadian researchers conducted an analysis of nearly two million people and found that people with acne are at greatest risk for major depression within a year of their diagnosis. Their risk of suffering from major depression during this time is 63 per cent higher than for people who do not suffer from the skin condition. Continue reading “Acne Patients at Significantly Higher Risk of Major Depression”

Unintended sunburn: the prevalence, risks and considerations

unintended sunburn

How often do people receive unintended sunburn, and how can sun protection messages be refined to target these people? Sunburn causes DNA damage to the skin, accelerates skin ageing, and increases a person’s lifetime risk of skin cancer. In fact, sustaining just five sunburns in youth increases a person’s melanoma risk by 80 per cent.

New Zealand has the highest melanoma incidence rate in the world. Primary prevention efforts focus on reducing sunburn incidence and improving sun protection habits among the population. However, sunburn from excessive UV exposure remains common. To reduce sunburn incidence, it is important to look at those individuals who experience unintended sunburn. Continue reading “Unintended sunburn: the prevalence, risks and considerations”

What is the effect of fluorouracil cream on photoageing?

photoageing

What is the effect of a standard course of topical fluorouracil cream on photoageing? Photoageing – premature skin ageing caused by long-term UV exposure – is of aesthetic concern to many patients. A study in JAMA Dermatology investigated the effect of topical fluorouracil (five per cent) cream in treating the condition.

The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial was a randomised clinical trial of 932 United States veterans with a recent history of two or more keratinocyte carcinomas performed from September 2011 to June 30 2014, to assess the chemo-preventive effects of a standard course of topical fluorouracil. Continue reading “What is the effect of fluorouracil cream on photoageing?”

Is Sunscreen Effective in Preventing DNA Damage?

DNA damage

Are topical sunscreens effective in preventing UV radiation-induced DNA damage in vivo?

There is strong evidence that topical sunscreens, designed to protect against UV radiation-induced erythema, decrease the amount of UVR to which the skin is exposed. However, their effectiveness in reducing UV radiation-induced DNA damage in vivo has not been well quantified. Continue reading “Is Sunscreen Effective in Preventing DNA Damage?”

Best Dilution of Corticosteroid to Treat Alopecia

corticosteroid

What is the best dilution of corticosteroid in the treatment of alopecia areata in adults? A study in the Journal of Dermatological Treatment compared the clinical efficacy and safety of triamcinolone acetonide and betamethasone dipropionate injections at different concentrations in scalp and beard alopecia.

Intralesional injection of triamcinolone acetonide and betamethasone dipropionate in three different dilutions (1/4, 1/8 and 1/12) and saline (control) was randomly applied to a total of 231 alopecia patches in 83 patients. Continue reading “Best Dilution of Corticosteroid to Treat Alopecia”

Is there a causal relationship between dysbiosis and atopic dermatitis?

dysbiosis

Is there a causal relationship between dysbiosis and atopic dermatitis? A study in the British Journal of Dermatology looked at the skin microbiome in atopic dermatitis and addressed whether there is a causal relationship between dysbiosis – a microbial imbalance inside the body – and atopic dermatitis.

Dysbiosis is a hallmark of atopic dermatitis, but the composition of skin microbiome communities and the causality of dysbiosis in atopic dermatitis have not been well established. Continue reading “Is there a causal relationship between dysbiosis and atopic dermatitis?”

Treating Female Pattern Hair Loss

pattern hair loss

Are oral antihypertensives effective in stimulating hair growth for women with pattern hair loss? A study in the International Journal of Dermatology sought to determine the efficacy of minoxidil and spironolactone in treating female pattern hair loss.

Women newly diagnosed with a Sinclair stage 2-5 pattern hair loss were scored for hair shedding and hair density before and after one year of treatment with oral minoxidil 0.25mg and spironolactone 25mg. Continue reading “Treating Female Pattern Hair Loss”

Treatment of Vulvar Lichen Sclerosus

vulvar lichen sclerosus

A recent study published in the Journal of Dermatological Treatment sought to assess the efficacy and safety of combining a potent corticosteroid with a retinoid in the treatment of vulvar lichen sclerosus.

Researchers retrospectively compared 21 patients treated with mometasone furoate and tretinoin in short-contact therapy (Group A), and 20 patients treated with cold cream and mometasone furoate (Group B) for five consecutive days per week for 12 weeks. Continue reading “Treatment of Vulvar Lichen Sclerosus”

Biologic Treatments for Elderly Patients with Psoriasis

elderly patients with psoriasis

How safe and effective are biologic treatments for elderly patients with psoriasis? The number of elderly psoriasis patients is steadily increasing. However, biologic treatment is generally considered to be challenging in older patients due to their increased risk of complications compared with younger patients.

A retrospective study in Japan aimed to evaluate the safety and efficacy of biologics in psoriasis patients aged over 75 years. Continue reading “Biologic Treatments for Elderly Patients with Psoriasis”

What is the link between obesity and rosacea?

obesity

What is the link between obesity and rosacea? This poorly understood relationship was the focus of a study recently published in the Journal of the American Academy of Dermatology.

The cohort study was the first to determine the association between obesity and the risk of incident rosacea, and included 89,886 participants from the Nurses’ Health Study II (1991-2005).

Over 14 years of follow up, the researchers identified 5,249 incident cases of rosacea. The risk of rosacea was elevated for people with increased body mass index. Continue reading “What is the link between obesity and rosacea?”